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6 year oldIn 1961, Lee and Jack Kirby created The Fantastic Four for Marvel Comics and went on to create titles including Spider-Man and The Incredible Hulk.
Lee's wife, Joan, died in 2017 - also aged 95 - but he is survived by his daughter, JC Lee.
Speaking to celebrity news website TMZ, JC said her father was "the greatest, most decent man".
The legendary comic book author died at Cedars Sinai Medical Center in Los Angeles on Monday after a medical emergency, according to Variety magazine.
In recent years, Lee had periodically suffered from illnesses, including a bout of pneumonia, US media reported.
Bob Iger, chairman of the Walt Disney Company, which bought Marvel Comics for $4bn (£2.5bn) in 2009, called Lee "a super hero in his own right" in a statement.
"The scale of his imagination was only exceeded by the size of his heart."
Lee was known for making a cameo in every Marvel film, though he had left the Marvel company in 1972. He remained chairman emeritus.
The Marvel superheroes Lee had a hand in creating, including Iron Man and Captain America, have resulted in some of Hollywood's highest grossing films, with the latest Marvel film, Infinity War, earning over $1.5bn (£1.1bn).
On Sunday, Veteran's Day, his official Facebook page shared a photograph of Lee in the Army, noting his nickname during World War Two was Playwright.
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