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8 year oldThe singer told Vanity Fair magazine that she felt, at the time, like she had made "the worst decision" of her life.
The 28-year old goes on to say that she "loves her son more than anything" but admits she really struggled adjusting to motherhood.
"I was obsessed with my child. I felt very inadequate," she says.
Angelo is now four and Adele's only child with partner Simon Konecki.
He advised her to talk to other mothers about her concerns. She says she refused at first but the depression "lifted" once she confided in a friend who had a child and realised she wasn't alone.
She goes on to say that taking an afternoon a week to herself improved the situation.
"A friend of mine said, 'Really? Don't you feel bad?' I said, 'I do, but not as bad as I'd feel if I didn't do it.' It makes you a better mum if you give yourself a better time."
On the cover: @Adele talks postpartum depression, Donald Trump, and befriending Beyoncé https://t.co/1syFQai1aD pic.twitter.com/GWTgMBXfeg
— VANITY FAIR (@VanityFair) October 31, 2016
The interview comes as Adele reaches the end of her 10-month tour to mark her album 25. She admits she still feels uncomfortable spending time away from her son.
"I'm enjoying touring, but at times I feel guilty because I'm doing this massive tour, and even though my son is with me all the time, on certain nights I can't put him to bed.
"I never feel guilty when I'm not working," she adds.
"You're constantly trying to make up for stuff when you're a mum. I don't mind, because of the love I feel for him."
Jessica Forster, who had postnatal depression, felt 'angry at her child, angry at herself' https://t.co/FssViQ8JfU https://t.co/aMDjl1L6ZF
— Victoria Derbyshire (@VictoriaLIVE) November 1, 2016
The singer also spoke of how her stage fright is so bad that she may never tour again.
"I'd still like to make records, but I'd be fine if I never heard [the applause] again. I'm on tour simply to see everyone who's been so supportive."
Looking ahead to new material Adele reveals that she thinks she "will never write songs as good as the ones that are on 21", admitting "I was completely off my face" while writing the second album.
She says the success of tracks like Someone Like You were largely down to drinking two bottles of wine a night and chain-smoking on a regular basis.
"A drunk tongue is an honest one," she said. "I'm not as indulgent as I was then, and I don't have time to fall apart like I did then."
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