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3 year oldHeld to raise funds for the Metropolitan Museum of Art's Costume Institute, the Gala returns after being cancelled last year due to the coronavirus pandemic.
And although its famous guests must follow Covid-19 rules, including wearing masks indoors, that hasn't stopped many going for all-out glamour.
This year's costume theme is In America: A Lexicon of Fashion" - and the looks were inspired by everything from the Matrix film franchise to the Statue of Liberty.
The ball was co-hosted by pop star Billie Eilish, tennis player Naomi Osaka, actor Timothée Chalamet and poet Amanda Gorman.
One of the most talked-about looks of the night came from the publicity machine that is Kim Kardashian - who covered her face and body in an all-enveloping black outfit.
The custom design was devised by Demna Gvasalia, the creative director of fashion house Balenciaga.
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The 23-time Grand Slam winner Serena Williams made a statement of a more colourful kind, wearing a star-spangled bodysuit beneath a feather-laden pink cape.
Other attendees, meanwhile, brought along props to accompany their outfits.
Without apparent explanation, singer Frank Ocean carried a green robotic baby, while musician Grimes brandished a sword.
Among the last to arrive at the Gala was Rihanna - who has stolen the show at past events, with outfits including a Pope-inspired costume in 2018.
The singer and businesswoman turned heads once again as she posed in an all-black Balenciaga overcoat, while her boyfriend, rapper A$AP Rocky, swathed himself in a multicoloured quilt.
One celebrity who wasn't there was rapper Nicki Minaj, who said she hadn't yet had a Covid vaccine, which was a requirement of entry.